Significance of adiponectin in the risk of coronary lesions in patients with impaired glucose regulation
10.3760/cma.j.issn.1000-6699.2012.12.009
- VernacularTitle:脂联素在糖调节受损患者冠状动脉病变风险中的意义
- Author:
Shan HUANG
;
Wenfang PENG
;
Li JIANG
;
Weiqiong GU
;
Yin WANG
;
Weiqing WANG
- Publication Type:Journal Article
- Keywords:
Impaired glucose regulation;
Impaired fasting glucose;
Impaired glucose tolerance;
Adiponectin;
C-reactive protein;
Gensini score
- From:
Chinese Journal of Endocrinology and Metabolism
2012;(12):984-988
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of impaired glucose regulation and adiponectin (APN)with the clinical severity of coronary lesions.Methods A total of 210 cases of suspected coronary heart disease were examined by coronary artery angiography.The patients were differentiated as 4 groups:42 patients with normal glucose tolerance (NGT),36 patients with impaired fasting glucose(IFG),92 patients with impaired glucose tolerance (IGT;including 44 cases with postpraudial 2h plasma glucose(2 hPG) ＜ 10 mmol/L as IGT1 subgroup and 48 cases with 2h PG ≥ 10 mmol/L as IGT2 subgroup),and 40 patients with combination of IFG and IGT.Accordingly,body mass index (BMI),blood pressure,blood lipid,insulin,APN and CRP were measured to evaluate by Gensini score.Results The incidence of coronary heart disease and Gensini scores in IGT and IGT+IFG groups were significantly higher than those in either IFG or NGT subset(P＜0.05).APN in both IGT and IGT+IFG subsets was significantly lower than that in IFG or NGT subsets(P＜0.05),CRP values were significantly raised in both IGT and IGT+IFG subgroups compared with the other 2 subgroups(P＜0.05).Statistical difference in Gensini scores and APN was found between the 2 IGT subgroups (P＜0.05).Gensini scores were negatively correlated with APN level.Multivariate regression analysis showed that both APN and HOMA-IR values were independently correlated with the Gensini scores.Conclusion The lowered APN may serve as a more sensitive factor in predicting the coronary lesions in patients with IGR,especially in IGT cases.It woula be beneficial to cardiovascular complication by controlling the postprandial blood glucose level below 10 mmol/L.
