Benefits and risks of bisphosphonate therapy for osteoporosis
10.3760/cma.j.issn.1000-6699.2012.12.002
- VernacularTitle:如何权衡二膦酸盐类药物治疗骨质疏松症的利与弊?
- Author:
Zhifeng SHENG
;
Eryuan LIAO
- Publication Type:Journal Article
- Keywords:
Bisphosphonates;
Benefits;
Risks;
Osteoporosis
- From:
Chinese Journal of Endocrinology and Metabolism
2012;(12):953-955
- CountryChina
- Language:Chinese
-
Abstract:
Bisphosphonates have been efficacious in preventing bone loss and reducing fractures in men and postmenopausal women with osteoporosis.Possible risks of osteonecrosis of the jaw and atypical femur fractures have been reported with bisphosphonates treatment,despite these incidences are very low.Oral bisphosphonates are associated with upper gastrointestinal side effects and iv bisphosphonates with acute phase reactions,the association of bisphosphonate use with esophageal cancer and atrial fibrillation is not well supported by current data.
