Approach to the patient with type B insulin resistance
10.3760/cma.j.issn.1000-6699.2012.11.021
- VernacularTitle:B型胰岛素抵抗的临诊应对
- Author:
Huibin HUANG
;
Wei LIN
;
Chunhua WANG
;
Lixiang LIN
;
Gang CHEN
- Publication Type:Journal Article
- Keywords:
Type B insulin resistance;
Systemic lupus erythematosus;
Diagnosis;
Treatment
- From:
Chinese Journal of Endocrinology and Metabolism
2012;(11):938-940
- CountryChina
- Language:Chinese
-
Abstract:
Type B insulin resistance (TBIR) is a rare disease caused by the presence of insulin receptor autoantibodies (IRA).African middle-aged women are predisposed to it.Most patients have an underlying autoimmune disease,most commonly systemic lupus erythematosus (SLE).The patients predominantly present with abnormalities of glucose homeostasis ranging from extreme insulin resistance and symptomatic hyperglycemia to lifethreatening hypoglycemia,usually accompanied with manifestation of insulin resistance such as acanthosis nigricans,hyperandrogenism,and polycystic ovary.The diagnosis can be established by the elevation of IRA.We herewith report a ease of TBIR complicated with SLE,and the clinical features,diagnosis and treatment of TBIR are reviewed.
