Improvement of high-fructose-feeding-induced fatty liver by oxymatrine intervention
10.3760/cma.j.issn.1000-6699.2012.11.020
- VernacularTitle:氧化苦参碱对高果糖饮食诱导大鼠脂肪肝的改善作用及机制研究
- Author:
Luping REN
;
Zhijuan HU
;
Guangyao SONG
;
Shuchun CHEN
;
Na LIU
;
Limin WEI
- Publication Type:Journal Article
- Keywords:
Oxymatrine;
Triglyceride;
Fatty liver
- From:
Chinese Journal of Endocrinology and Metabolism
2012;(11):935-937
- CountryChina
- Language:Chinese
-
Abstract:
The effect of oxymatrine on high-fructose-feeding induced insulin resistance and liver steatosis in rats was observed and the underlying mechanism in improving the hepatic lipid metabolism was explored.The results demonstrated that high fructose feeding decreased the glucose tolerance and increased hepatic lipid accumulation in rats,while oxymatrine could improve glucose tolerance and alleviate hepatic steatosis in rats.High fructose feeding stimulated the protein expressions of key lipid-synthesis enzymes,which were decreased by oxymatrine intervention.Both high fructose feeding and oxymatrine intervention had no significant effect on protein expressions of mitochondrial fatty acid oxidation enzymes.
