Effects of artificial cordyceps sinensis on epithelial-mesenchymal transition in the podocytes of diabetic rats
10.3760/cma.j.issn.1000-6699.2012.11.018
- VernacularTitle:人工虫草对糖尿病大鼠足细胞上皮间质转分化影响的研究
- Author:
Yunying CAI
;
Zhongshu MA
;
Mingcai QIU
- Publication Type:Journal Article
- Keywords:
Artificial cordyceps sinensis;
Diabetic nephropathy;
Podocyte;
Epithelial-mesenchymal transition;
Monocyte chemoattractant protein-1
- From:
Chinese Journal of Endocrinology and Metabolism
2012;(11):927-931
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effects of artificial cordyceps sinensis(Jin shuibao) on the numbers of podocytes and epithelial-mesenchymal transition in diabetic rats.Methods Diabetes was induced by intraperitoneal injection of low dose streptozocin.Sprague-Dawley rats were randomly divided into three groups:control group (CON),diabetic model group(DM),and artificial cordyceps sinensis treatment group(CS).After intervention for 8 weeks,the numbers of podocytes were estimated hy immunohistochemistry.The expressions of nephrin,desmin,and monocyte chemoattractant protein-1 (MCP-1) were detected.Results Compared with control group,DM group showed significantly decreased podocyte numbers and nephrin mRNA,with increased desmin and MCP-1 levels(P＜0.05).While the numbers of podocytes and nephrin mRNA were increased,and the expressions of desmin and MCP-1 were decreased in CS group as compared with those in DM group (all P＜0.05).Conclusions Artificial cordyceps sinensis notably improves epithelial-mesenchymal transition of podocytes,and increases the number of podocytes in diabetic rats.
