The correlation between the adiponectin gene SNP+276G/T, SNP+45T/G with metabolic syndrome
10.3760/cma.j.issn.1000-6699.2012.11.013
- VernacularTitle:脂联素基因SNP+276G/T、SNP+45T/G与代谢综合征的相关性研究
- Author:
Fengzhen HUANG
;
Jun LIU
;
Dong PANG
;
Peili BU
- Publication Type:Journal Article
- Keywords:
Adiponectin;
Polymorphism;
single nucleotide;
Metabolic syndrome
- From:
Chinese Journal of Endocrinology and Metabolism
2012;(11):911-913
- CountryChina
- Language:Chinese
-
Abstract:
Two hundred and twenty-four patients with metabolic syndrome (MS) and 200 subjects as normal controls were included in this study.Genotyping of +276G/T,+45T/G SNPs in apM1 gene was made by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique,and then the distribution and differences in genotypes and allele frequencies in the population were observed.It was found that the G/T polymorphism of +276 site was associated with MS,while +45 T/G polymorphism had nothing to do with MS.It is suggested that the +276G/T polymorphism may be a predisposing factor of MS.
