Association of plasma t-PA and PAI-1 with carotid atherosclerosis in patients with type 2 diabetes
10.3760/cma.j.issn.1000-6699.2012.11.011
- VernacularTitle:2型糖尿病患者血浆t-PA、PAI-1水平与颈动脉粥样硬化关系
- Author:
Yuanzhen KONG
;
Qiqian ZHU
;
Lingxiao WANG
;
Yafang ZHOU
;
Jianfei ZHANG
- Publication Type:Journal Article
- Keywords:
Tissue type plasmingogen activator;
Plasminogen activator inhibitor-1;
Carotid atherosclerosis;
Diabetes mellitus,type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2012;(11):905-907
- CountryChina
- Language:Chinese
-
Abstract:
The association of plasma tissue type plasmingogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) with carotid atherosclerosis in patients with type 2 diabetes was explored.The subjects with type 2 diabetes (n =91) and control subjects (n =30) were enrolled for this study.According to carotid artery intima media thickness in Color Doppler Ultrasonography,the subjects with type 2 diabetes were divided into four groups:normal carotid group(group 1,n =25),lining thickening group (group 2,n =30),stable plaques group (group 3,n =23),carotid stenosis group(group 4,n =13).Plasma t-PA and PAI-1 levels were measured by ELISA.Compared with the control group,there was no significant change in the levels of plasma t-PA and PAI-1 in group 1 (P＞0.05),plasma t-PA activity was decreased significantly(P＜0.05) and PAI-1 activity increased obviously (P＜0.05) in group 2,group 3,and group 4.Carotid atherosclerosis degree was negatively correlated with t-PA(r=-0.723,P＜0.01) and positively correlated with PAI-1 (r=0.851,P＜0.01).The results suggested that the abnormal fibrinolysis function may take part in the development of atherosclerosis of carotid arteries in patients with type 2 diabetes.
