The potential mechanisms of GLP-1 and gastrointestinal reaction

VernacularTitle:利拉鲁肽对胃肠道作用的机制探讨
Author: Guang NING
Publication Type:Journal Article
Keywords: Liraglutide; Glucagon like peptide-1; Diabetes,type 2; Gastrointestinal adverse event
From: Chinese Journal of Endocrinology and Metabolism 2012;(11):951-954
CountryChina
Language:Chinese
Abstract: Liraglutide is a long-acting human GLP-1 analogue,which provides pharmacological level of GLP-1 and combines with GLP-1 receptor widely distributing in the body.Liraglutide demonstrates multiple antidiabetic and other effects,including glucose-dependent glucose-lowering action,pancreatic islet cells protection,gastric emptying inhibition,appetite reduction/feelings of satiety and fullness increasing,weight loss,cardioprotection and blood pressure lowering action.Meanwhile,clinical practice also shows that some gastrointestinal adverse events occur accompanying with good glucose control and weight loss.This review will explain the potential mechanisms of GLP-1 and gastrointestinal reaction,clinical evidence of liraglutide and effective management rules,aim to help readers better understand this issue,as well as to advise clinicians of proper use of liraglutide while reducing or avoiding those adverse events.