β cell dedifferentiation: new insight into the pathogenesis of β cell failure in type 2 diabetes——Gone backward already...and Coming back again?
10.3760/cma.j.issn.1000-6699.2012.11.002
- VernacularTitle:β细胞去分化:2型糖尿病β细胞功能衰竭机制新解——能“去”…还能“回”?
- Author:
Jianmin LIU
- Publication Type:Journal Article
- Keywords:
Diabetes;
β cell;
Dedifferentiation
- From:
Chinese Journal of Endocrinology and Metabolism
2012;(11):871-873
- CountryChina
- Language:Chinese
-
Abstract:
β cell failure is one of the important components in the pathogenesis of type 2 diabetes.Protecting and reversing β cell function is a critical part in diabetes treatments.It has been recently discovered that rather than apoptosis,β cell dedifferentiation into an endocrine progenitor-like stage is the main mechanism of β cell failure,which is closely related with the loss of FoxO1 on β cells.Some of these dedifferentiated β cells even have the potency to convert into α-cells.These great discoveries expand our understanding for the β cell exhaustion during the progression of hyperglycemia.It is worthwhile to reconsider our current treatment strategy for type 2 diabetes,especially during the beginning period,to protect rather than stimulate β cells.It also paves the way to develop a brand-new class of hypoglycemic agent to re-differentiate the already dedifferentiated β cells back into insulinsecreting cells.
