Blood-saving effect of tranexamic acid in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass
10.3760/cma.j.issn.0254-1416.2012.12.012
- VernacularTitle:氨甲环酸对体外循环冠状动脉旁路移植术患者的血液保护作用
- Author:
Jia SHI
;
Su YUAN
;
Qinghua XUE
;
Guyan WANG
;
Yuefu WANG
;
Lihuan LI
- Publication Type:Journal Article
- Keywords:
Extracorporeal circulation;
Tranexamic acid;
Blood transfusion
- From:
Chinese Journal of Anesthesiology
2012;(12):1460-1462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the blood-saving effect of tranexamic acid in patients undergoing coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB).Methods The study was a prospective,randomized and placebo-control trial.Two hundred ASA Ⅰ-Ⅳ patients,aged 18-64 yr,weighing 50-100 kg,were randomized to receive placebo (group C,n =100) or tranexamic acid (group T,n =100).Tranexamic acid 10 mg/kg was intravenously infused over 20 min before skin incision followed by continuous infusion at 10 mg· kg-1 · h-1 until the end of operation in group T.While the equal volume of normal saline was given in group C.The total volume of postoperative chest tube drainage,postoperative massive bleeding and a second thoracotomy for stopping the bleeding were reordered.The requirement for transfusion of allogeneic blood and complications during the perioperative period were also recorded.Results Compared with group C,the total volume of postoperative chest tube drainage and incidences of postoperative massive bleeding and a second thoracotomy for stopping the bleeding were significantly decreased,and the requirement for transfusion of allogeneic red blood cells,platelet and fresh frozen plasma was reduced in group D (P ＜ 0.05).There was no significant difference in the incidence of complications between the two groups (P ＜ 0.05).Conclusion Tranexamic acid exerts the blood-saving effect in patients undergoing CABG with CPB and can significantly reduce postoperative bleeding and transfusion of allogeneic blood.
