Effect of dexmedetomidine on intraoperative wake-up test during cerebral functional area operation performed under combined intravenous propofol-remifentanil anesthesia
10.3760/cma.j.issn.0254-1416.2012.10.023
- VernacularTitle:右美托咪定对丙泊酚复合瑞芬太尼麻醉下脑功能区手术患者唤醒试验质量的影响
- Author:
Jing TIAN
;
Zhiyong WANG
;
Yonghao YU
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Propofol;
Piperidines;
Neurosurgical procedures;
Wake-up test
- From:
Chinese Journal of Anesthesiology
2012;(10):1243-1245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evatluate the effect of dexmedetomidine on intraoperative wake-up test during cerebral functional area operation performed under combined iv propofol-remifentanil anesthesia.Methods Twenty-seven ASA Ⅰ or Ⅱ patients (both sexes) aged 17-43 yr with a body mass index of 20-24 kg/m2 undergoing op-eration on cerebral functional area during which intraoperative wake-up test was performed were randomly divided into control group (group C,n =13) and dexmedetomidine group (group D,n =14).Anesthesia was induced with midazolam,sufentanil,etomidate and rocuronium and maintained with TCl of propofol (Cp =3-5 μg/ml) and remifentanil (Ce =2-6 ng/ml).BIS value was maintained at 55-65.In group D after dura of brain was opened,a loading dose of dexmedetomidine 0.3 μg/kg was administered iv over 15 min followed by continuous iv infusion at 0.2 μg· kg-1 · h-1 while TCI of propofol and remifentanil were suspended.In group C after opening of dura,Cp of propofol TCI was reduced to 0.5 μg/ml and Ce of remifentanil to 0.5 ng/ml.The wake-up time and development of hypertension,tachycardia,headache,dysphoria,delirium and awareness were recorded.Results All patients were successfully awakened.There was no significant difference in wake-up time between the 2 groups (P ＞0.05).The incidences of hypertension,tachycardia,headache and awareness were significantly lower in group D than in group C (P ＜ 0.05).Conclusion Dexmedetomidine does not affect intraoperative wake-up time during operation on cerebral functional area performed under iv propofol-remifentanil anesthesia,but can significantly reduce the incidence of adverse effects.
