Antidepression therapy on symptom and quality of life in elderly benign prostatic hyperplasia with depression
10.3760/cma.j.issn.0254-9026.2013.02.013
- VernacularTitle:抗抑郁治疗对老年良性前列腺增生合并抑郁患者的影响
- Author:
Lina MA
;
Ming FENG
;
Yun LI
;
Yuying QIAN
;
Hong ZHU
;
Wei YANG
- Publication Type:Journal Article
- Keywords:
Prostatic hyperplasia;
Antidepressive agents;
Quality of life
- From:
Chinese Journal of Geriatrics
2013;(2):168-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of antidepression therapy on symptom score and quality of life in elderly benign prostatic hyperplasia with depression.Methods A total of 94 elderly patients with benign prostatic hyperplasia and depression were randomly divided into two groups:control group (regular drugs) and therapy group adding citalopram 20 mg,once daily for 3 months.The changes of internatio nal prostate sympeom score (IPSS) symptom score,hamilton depression (HAMD) and scores of short form (36) health survey before and after treatment were compared between the two group.Results After treatment,IPSS symptom score [(10.74 ± 4.72) vs.(16.42±8.09)] was much lower in therapy group than in control group (t=4.16,P＜0.05).Each dimension of quality of life was increased after antidepression treatment [physical function (67.75 ± 9.99) vs.(63.09±7.90),SF-36 role physical (70.90±10.85) vs.(62.81±9.16),bodily pain indices (72.75± 10.59) vs.(63.13 ± 9.47),general health (62.59 ± 9.38) vs.(53.67 ± 7.52),vitality (64.09±8.96) vs.(58.11 ± 7.87),social functioning (71.84 ± 6.87) vs.(64.99 ± 7.21),roleemotional (70.15±9.93) vs.(65.01±9.18),mental health (68.74±8.23) vs.(61.77±7.83),all P＜0.05].Conclusions More attention should be paid to antidepression therapy in the elderly with benign prostatic hyperplasia and depression.
