Relationship between glycosylated hemoglobin and pulse wave velocity in non-diabetic elderly people

VernacularTitle:老年非糖尿病者糖化血红蛋白与脉搏波速度相关性分析
Author: Yan ZHANG ; Shuwen YANG ; Jing FU ; Yuehua SONG ; Lanjun MA ; Ling ZHU
Publication Type:Journal Article
Keywords: Hemoglobin A,glycosylated; Pulse
From: Chinese Journal of Geriatrics 2012;(12):1041-1043
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between glycosylated hemoglobin and pulse wave velocity in non-diabetic elderly people.Methods Totally 163 subjects were included after exclusion of liver or kidney disfunction,diabetes mellitus or malignant tumor.They were divided into two groups:group A (HbA1c＜5.7％) (n＝54) and group B (HbA1c 5.7％-6.4％)(n＝109).The age,pulse wave velocity,systolic blood pressure,diastolic blood pressure,blood chemistry and hypertension were compared between the two groups.Multi factor analyse was conducted to analyze the relative factors for pulse wave velocity.Results Systolic blood pressure was higher in group B than in group A (P ＜ 0.05).Multi-linear stepwise regression analyses suggested that age,hypertension,glycosylated hemoglobin were positively related to pulse wave velocity in non-diabetic elderly people (β values were 20.382,144.061,93.195,all P＜0.10).Conclusions Glycosylated hemoglobin is related to arterial stiffness in non-diabetic elderly people,it can be used as a predictive and control target of cardiovascular and cerebrovascular disease in old people.