Effect of vascular endothelial growth factor and phosphoinositide 3-kinase in retinopathy of prematurity
10.3760/cma.j.issn.1673-4408.2013.01.027
- VernacularTitle:血管内皮生长因子与磷脂酰肌醇3-激酶/蛋白激酶B信号传导通路在早产儿视网膜病变中的作用
- Author:
Jing HUA
- Publication Type:Journal Article
- Keywords:
Retinopathy of prematurity;
Phosphoinositide 3-kinase signaling pathway;
Vascular endothelial growth factor
- From:
International Journal of Pediatrics
2013;(1):91-94
- CountryChina
- Language:Chinese
-
Abstract:
Vascular endothelial growth factor can induce angiogenesis in vivo.Phosphoinositide 3-kinase signaling pathway widespreads in cells,which plays important roles in cell growth,proliferation,differentiation,and angiogenesis.The phosphoinositide 3-kinase signaling pathway can activate vascular endothelial growth factor,such as hypoxia-inducible factor-1,insulin-like growth factor-Ⅰ,nitric oxide synthaseand cyclooxygenase-2.The present studies have shown that the vascular endothelial growth factor and phosphoinositide 3-kinase signaling pathway play an important role in the retinopathy of prematurity.
