FcγR gene polymorphisms in Kawasaki disease susceptibility and the efficacy of intravenous immunoglobulin therapy
10.3760/cma.j.issn.1673-4408.2013.01.023
- VernacularTitle:FcγR基因多态性与川崎病遗传易患性及静脉免疫球蛋白疗效的研究进展
- Author:
Liyun ZHENG
- Publication Type:Journal Article
- Keywords:
FcγR;
Gene polymorphisms;
Kawasaki disease;
Susceptibility;
Immunoglobulins intravenous
- From:
International Journal of Pediatrics
2013;(1):77-80
- CountryChina
- Language:Chinese
-
Abstract:
Fcgamma receptors family conclude three groups(CD64、CD32、CD16),of which FcγR Ⅱa,Ⅱb,Ⅲb have Gene polymorphisms,for this reason they have an effect on affinity of FcγR to antibodies different,so FcγRⅡa,Ⅱb,Ⅲb are related to genetic susceptibility and IVIG treatment response.The Gene subtype of FcγR Ⅱ a is considered to be the susceptibility genes of KD.Polymorphisms of FcγRs were intimately connected to pathogenesis,coronary artery impairment and disease prevention of Kawasaki disease.
