Advances in the molecular genetics of the ankylosing spondylitis
10.3760/cma.j.issn.1673-4408.2012.06.014
- VernacularTitle:强直性脊柱炎的分子遗传学研究进展
- Author:
Junjie LI
;
Jiafen JI
- Publication Type:Journal Article
- Keywords:
Ankylosing spondylitis;
Heredity;
Molecular biology;
Gene
- From:
International Journal of Pediatrics
2012;(6):588-590
- CountryChina
- Language:Chinese
-
Abstract:
Ankylosing spondylitis (AS) is a chronic rheumatic disease involving the spine and sacral hip.AS is the prototype disease of seronegative arthritis of the spine.Besides the violations of the spine,AS can also lead to violations of the peripheral joints,even the eyes,intestine,aortic root,and other tissues and organs.The pathogenesis of AS has remained unclear.AS,a genetic disease,is influenced by the genetic and environmental factors.Studies have suggested that HLA-B27 is the most critical genes to AS,and forming three kinds of hypotheses associated with HLA-B27.This paper reviews the molecular genetics and pathogenesis of AS.
