Basic research of the interaction between chemotherapy agent and magnesium isoglycyrrhizinate
10.3760/cma.j.issn.1007-8118.2012.12.014
- VernacularTitle:异甘草酸镁与化疗药的相互作用的基础研究
- Author:
Linzhong ZHU
;
Tao NING
;
Xu ZHU
- Publication Type:Journal Article
- Keywords:
Magnesium isoglycyrrhizinate;
Chemotherapy agents;
Interaction of drugs
- From:
Chinese Journal of Hepatobiliary Surgery
2012;(12):944-947
- CountryChina
- Language:Chinese
-
Abstract:
Objective Under the circumstance of continuous arterial infusion,role of magnesium isoglycyrrhizinate combined with different kinds of chemotherapy agents respectively were detected on the HepG-2 and 7702cell lines.Method MTT assay in cultured HepG-2 and 7702 in vitro were used to detect different chemotherapy agents combined with transemetil with different sequence; interaction of MgSO4 with chemotherapy agents were observed in HepG-2 cell lines.Results When combined with docetaxel,gemcitabine,epirubicin,5 fluorouracil,pemetrexed disodium,magnesium isoglycyrrhizinate had synergistic effect; when combined with other agents,there were no antagonism effect; 4 kinds of chemotherapy agents had slight synergistic effect with magnesium sulfate.Conclusion Magnesium isoglycyrrhizinate showed obvious synergistic effect when combined with chemotherapy agents; different sequence between magnesium isoglycyrrhizinate and chemotherapy agents showed different effect; the mechanism need more study.
