A comparison of dual- and triple-freeze protocols for liver cryoablation in a Tibet pig
10.3760/cma.j.issn.1007-8118.2012.11.016
- VernacularTitle:不同循环冷冻消融术对西藏小型猪肝部冷冻消融效果的比较
- Author:
Fei YAO
;
Jianying ZENG
;
Jibing CHEN
;
Liang ZHOU
;
Weiqun LIU
;
Binghui WU
;
Gang FANG
;
Chunjuan DENG
;
Zhixian CHEN
;
Yin LENG
;
Min DENG
;
Bo ZHANG
;
Chunmei DENG
;
Jialiang LI
;
Lihua HE
;
Lizhi NIU
;
Jiansheng ZUO
;
Kecheng XU
- Publication Type:Journal Article
- Keywords:
Liver;
Cryoablation;
Tibet pig model
- From:
Chinese Journal of Hepatobiliary Surgery
2012;(11):867-870
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study compares a dual-freeze protocol with a triple freeze protocol for hepatic cryoablation in the Tibetan pig model.Method Cryoablation with a dual-(10-5-10-5 min)and triple-freeze (5-5-5-5-10-5 min) protocol for the normal livers of 9 Tibet pigs was performed under exposed operation.Temperature changes of cryoprobes and diameter changes of iceballs were measured during the ablation,and seven days later the pathological changes of cryozones were reviewed and the surface and depth cryolesions were measured.Results Compared with cryoablation with two freeze-thaw cycles,there was a greater iceball diameter for cryoablation by three freeze-thaw cycles.Also,seven days after cryosurgery,there were similar surface and deep cryolesions in dual-and triple-freeze protocols.Pathologically,the triple freezing protocol was associated with a longer zone of complete necrosis.Conclusions With the same freezing time (20 min),the triple-freeze protocol may become a more powerful liver-ablation method in cryosurgical application.
