Progress of genetic polymorphisms in neonatal necrotizing enterocolitis
10.3760/cma.j.issn.1673-4408.2012.06.013
- VernacularTitle:新生儿坏死性小肠结肠炎遗传多态性研究进展
- Author:
Weiming YUAN
- Publication Type:Journal Article
- Keywords:
Neonatal necrotizing enterocolitis;
Single nucleotide polymorphisms
- From:
International Journal of Pediatrics
2012;(6):585-588
- CountryChina
- Language:Chinese
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Abstract:
Neonatal necrotizing enterocolitis (NEC) is still a disease with high mortality and morbidity in neonates.The pathogenesis of NEC is not quite clear.Inflammatory cascade,innate immune response and intestinal blood flow are thought to play significant roles in the machinism of NEC.Single nuleotide polymorhism (SNP) is characterized by single nucleotide mutation in the genecome consequences.They may alter the susceptibility to some kinds of diseases by changing the efficiency of transcription or the structure of protein coded by the related gene.This review summarizes the progress of the research on genetic polymorphisms in neonatal necrotizing enterocolitis.
