Analysis of treatment outcome for stage Ⅲ thymoma
10.3760/cma.j.issn.1004-4221.2012.06.009
- VernacularTitle:111例Ⅲ期胸腺瘤治疗结果分析
- Author:
Chengcheng FAN
;
Qinfu FENG
;
Yousheng MAO
;
Yidong CHEN
;
Yirui ZHAI
;
Hongxing ZHANG
;
Dongfu CHEN
;
Zefen XIAO
;
Jian LI
;
Zongmei ZHOU
;
Jun LIANG
;
Jima Lü
;
Zhouguang HUI
;
Lühua WANG
;
Jie HE
- Publication Type:Journal Article
- Keywords:
Thymus neoplasms/surgery;
Thymus neoplasms/radiotherapy;
Combined modality therapy;
Treatment outcome
- From:
Chinese Journal of Radiation Oncology
2012;(6):513-517
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze survival and recurrence rates of patients with Masaoka stage Ⅲ thymoma and to explore the prognostic factors.Methods Between September 1965 and December 2010,a total of 111 patients with stage Ⅲ thymoma treated in our hospital were retrospectively analyzed.Sixty-eight patientsreceived comple te rescction ± radiotherapy,whilc 23 patients received incomplete resection ±radiotherapy and 20 patients received biopsy ± radiotherapy.Eighty-seven patients received postoperative radiotherapy (12 patients received preoperative radiotherapy) while 24 patients received surgery alone.Results The median follow-up time was 66 months (5-540) with a follow-up rate of 92.5％ (111/120).Compared with incomplete resection ± radiotherapy and biopsy ± radiotherapy,the 5-year overall survival (OS) (88％ vs.59％ and 57％,x2 =12.11,P =0.002),disease free survival (DFS) (74％ vs.40％ and 41％,x2 =11.49,P =0.003) and disease specific survival (DSS) (94％ vs.69％ and 60％,x2 =10.95,P =0.004) could be improved with complete resected ± radiotherapy.Compared with surgery alone,postoperative radiotherapy did not improve OS,DFS and DSS (55％ vs.77％ (x2 =1.01,P =0.316),61％vs.61％ (x2 =0.12,P =0.729) and 72％ vs.85％ (x2 =0.27,P =0.601),respectively).For the 68 patients received complete resection,radiotherapy after complete resection (56 patients) did not improve OS,DFS and DSS (82％ vs.89％ (x2 =0.31,P =0.576),72％ vs.81％ (x2 =0.05,P=0.819) and 89％vs.95 ％ (x2 =0.05,P =0.825),respectively) compared with surgery alone (8 patients).Conclusions Stage Ⅲ thymoma patients received complete resection had better outcome than patients received incomplete resection or biopsied only.The role of postoperative radiotherapy is still controversial for stage Ⅲ thymoma,randomized clinical trial is needed
