The relevance between single nucleotide polymorphism in the downstream of Toll-like receptor signal transduction pathway and rheumatoid arthritis susceptible genes
10.3760/cma.j.issn.1007-7480.2013.02.002
- VernacularTitle:Toll样受体信号传导通路下游分子单核苷酸多态性与类风湿关节炎易感基因的关联
- Author:
Xi LIU
;
Jing XU
;
Chengdong HU
;
Zhenglun PAN
;
Yuanchao ZHANG
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Polymorphism,single nucleotide;
Disease susceptibility;
TNF receptor-associated factor 6;
Receptors,interleukin-6;
Myd88
- From:
Chinese Journal of Rheumatology
2013;(2):76-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between single nucleotide polymorphism (SNP) of downstream mononucleotide in signal transduction of Toll-like receptors and predisposing genes of rheumatoid arthritis (RA).Methods One hundred and sixty-two RA patients were selected from northern part of Han people in China,and 188 healthy subjects were enrolled as normal controls.Rs7744 of Myd88,rs5030445 of TRAF6,rs11265618 and rs4845626 of IL-6R were analyzed.The data of genotypic frequency and allele genotypic frequency were statistical analyzed by x2 test between the two groups.Results The difference of allele frequency of TRAF6 rs5030445 between the two groups were remarkable (x2=5.716,P＜0.05),and so did the IL-6R rs11265618 (x2=5.704,P＜0.05).But the difference of genotypic frequency was not statistically significant for locus of Myd88 rs7744,TRAF6 rs5030445 and IL-6R rs11265618 (P＞0.05).And the differenceof allele frequency and genotypic frequency between the two groups had no statistical significance in locus of Myd88 rs7744 and IL-6R rs4845626 (P＞0.05).Conclusion There is significant correlation between single nucleotide polymorphism and predisposing genes of RA.The G allele of TRAF6 rs5030445 gene locus is a possible predisposing gene for RA.The T allele of IL-6R rs11265618 is a possible predisposing gene of RA.
