Association between recurrent miscarriages and insulin resistance:a Meta analysis
10.3760/cma.j.issn.0529-567x.2012.12.009
- VernacularTitle:复发性流产与胰岛素抵抗相关性的荟萃分析
- Author:
Zelian LI
;
Huifen XIANG
;
Linghui CHENG
;
Yunxia CAO
;
Zhaolian WEI
;
Cheng LIU
;
Jingjing HU
;
Faming PAN
- Publication Type:Journal Article
- Keywords:
Abortion,habitual;
Insulin resistance;
Meta analysis
- From:
Chinese Journal of Obstetrics and Gynecology
2012;(12):915-919
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between recurrent miscarriages and insulin resistance.Methods The case-control studies on the association between recurrent spontaneous abortion and insulin resistance from June 1996 to April 2012 were collected from Medline,Elsevier,Chinese Journal Fulltext Database,Chinese Biological Medicine Database,data base of Wanfang,Springer link and EMBASE.RevMan 5.1 software was used for Meta analysis.Results According to the included criteria,7 clinical trials were finally selected.Total 467 cases with recurrent pregnancy loss were enrolled in study group,while 413 women with no history of abnormal pregnancies were enrolled in control group.No significant difference was found in average age and body mass index between the two groups (P ＞ 0.05).Meta analysis results showed that the level of fasting glucose was no statistical difference between study group and control group (WMD =2.27,95％ CI:-1.11 to 5.65,P ＞0.05); fasting insulin level was higher 2.05 mU/L in study group than that of in control group,the difference was statistically significant (WMD =2.05,95％ CI:1.03 to 3.08,P ＜ 0.01).Case number of study group on Homa-insulin resistance ＞ 4.5 was more than that of control group (OR =3.36,95％ CI:1.72 to 6.57,P ＜ 0.01).Case number of study group on glucose/insulin ratio ＜ 4.5 was more than that of the control group,statistical difference was found (OR =3.37,95％ CI:1.90 to 5.99,P ＜ 0.01).Conclusion Insulin resistance is associated with the susceptibility to recurrent miscarriages,and it may contribute to the occurrence of recurrent miscarriages.
