Efficiency comparison of preparing nano-scale microbubbles by oscillation and sonication
10.3760/cma.j.issn.1004-4477.2012.12.022
- VernacularTitle:机械振荡法与声振法制备纳米级微泡超声造影剂效能比较
- Author:
Jian ZHENG
;
Ping WANG
;
Tinghui YIN
;
Bowen ZHENG
;
Du CHENG
;
Rongqin ZHENG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Nanotechnology
- From:
Chinese Journal of Ultrasonography
2012;(12):1078-1081
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficiency of oscillation with sonication in preparing nano-scale microbubbles (NBs).Methods Nano-scale microbubbles were prepared using oscillation and sonication respectively,and then compared the NBs' size,size distribution,concentrations and time-consumption of the two methods.Results The sizes of nanobubbles prepared by sonication and oscillation were (373.88 ±18.43)nm and (360.74 ± 14.39)nm,respectively.There was no significant difference in size between the two methods (P =0.523).The polidispersity was larger in sonication before centrifugation,there was significant difference between the two methods (P ＜0.001).The concentration of nanobubbles prepared by oscillation was (1.48 ± 0.15) × 1010,which was higher than that by oscillation [(8.07 ± 0.62) × 108],there was significant difference between the two methods (P ＜ 0.001).The consuming time was shorter in oscillation,the difference was significant when compared with sonication (P ＜0.001).Conclusions Both two methods can successfully prepare NBs.Compared with sonication,oscillation can effectively produce NBs with smaller polidispersity,higher concentration and shorter time-consumption.
