Study on different threshold value in different size breast lesions using ultrasound-guided diffused optical tomography
10.3760/cma.j.issn.1004-4477.2012.11.017
- VernacularTitle:超声光散射断层成像对不同大小乳腺病灶的血红蛋白浓度诊断阈值探讨
- Author:
Shanshan YOU
;
Yuxin JIANG
;
Qingli ZHU
;
Mengsu XIAO
;
Hongyan WANG
;
Jing ZHANG
;
He LIU
;
Qing DAI
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Breast diseases;
Diffused optical tomography
- From:
Chinese Journal of Ultrasonography
2012;(11):973-976
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure total hemoglobin concentration (THC) of breast lesion using US-guided diffused optical tomography(DOT) and to investigate the THC optimal threshold value in different size breast lesions.Methods DOT was performed on 500 breast lesions and surgical pathology was as the gold standard.The optimal diagnostic threshold and the efficacy were figured out.Results There were 265 benign and 235 malignant lesions.In malignant lesions,THC of ≥2 cm lesion group was higher than that of ＜2 cm lesion group(P =0.000).In benign lesions,there was no statistical difference between ≥2 cm group and ＜2 cm group (P =0.13).As for ＜2 cm breast lesions,when a THC threshold value of 146.9 μmol/L and 102.2 μmol/L were used,the sensitivity,specificity,positive predictive value,negative predictive value and accuracy were 74.2％,70.0％,71.7％,62.9％,79.9％ and 86.7％,44.4％,61.6％,51.6％,83％,respectively.As for ≥2 cm breast lesions,when a THC threshold value of 210.4 μmol/L were used,the sensitivity,specificity,positive predictive value,negative predictive value and accuracy were 74.0％,86.7％,79.1％,89.2％,69.2％.Conclusions THC of breast cancer increased with the increasing size of lesions.The different diagnostic threshold value should be used according to different size lesions so as to enhance sensitivity,specificity and accuracy.
