Analysis of causes and risk factors of postpartum hemorrhage in hepatitis B virus-infected parturients
10.3760/cma.j.issn.1000-6680.2012.11.009
- VernacularTitle:乙型肝炎病毒感染产妇发生产后出血的原因和影响因素
- Author:
Yingting WU
;
Huifen CHEN
;
Qin ZHANG
;
Peiru JIANG
;
Weili ZHANG
;
Rong HAN
- Publication Type:Journal Article
- Keywords:
Hemorrhage,postpartum;
Hepatitis B;
Risk factors;
Hepatitis,chronic active
- From:
Chinese Journal of Infectious Diseases
2012;(11):682-685
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causes and risk factors of postpartum hemorrhage (PPH) in hepatitis B virus (HBV) infected parturient.Methods Retrospective analysis was performed on the 1021 HBV infected parturient from Shanghai Public Health Clinical Center from July 2005 to June 2011.The comparisons were done by chi-square test.Results Among 1021 cases of HBV infected parturient,868 (85.01％) were asymptomatic and the PPH rate was 2.76％ (24/868) ;the remaining 153 cases (14.99％) were chronic active hepatitis B and the PPH rate was 16.99％(26/153).The difference between two groups was statistically significant (x2 =56.541,P＜0.01).The total incidence rate of PPH was 4.89％ (50/1021) and 17 cases (34.00％) were postpartum hemorrhage＞1000mL.The causes of PPH included uterine inertia (30/50,60.00％),abnormal placenta (11/50,22.00％),dysfunction of coagulation (5/50,10.00％) and lesion of birth canal (4/50,8.00％).The risk factors of PPH included delivery mode (x2 =6.528,P=0.038),abortion times (x2 =16.269,P=0.000),delivery times (x2 =6.990,P=0.008),ALT levels (x2=56.541,P=0.000) and HBV DNA (x2 =64.706,P=0.000).Conclusions The main causes of PPH in HBV infected parturient include uterine inertia,abnormal placenta,lesion of birth canal and dysfunction of blood coagulation.PPH is correlated with abortion times,delivery times,delivery mode,liver function and HBV DNA.The incidence of PPH in parturient with chronic active hepatitis B is higher than asymptomatic parturient.
