4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Its Effects on Coronary Artery Disease.
10.4070/kcj.1998.28.7.1105
- Author:
Hyun Jae KANG
;
Ki Hoon HAN
;
Seong Choon CHOE
;
Hyo Soo KIM
;
Dae Won SOHN
;
Byung Hee OH
;
Myoung Mook LEE
;
Young Bae PARK
;
Yun Shik CHOI
;
Young Woo LEE
- Publication Type:Original Article
- Keywords:
Plasminogen activator inhibitor-1;
4G/5G polymorphism;
Coronary artery disease
- MeSH:
Acute Coronary Syndrome;
Alleles;
Angina, Stable;
Angina, Unstable;
Base Pairing;
Coronary Angiography;
Coronary Artery Disease*;
Coronary Vessels*;
Gene Frequency;
Humans;
Myocardial Infarction;
Plasma;
Plasminogen Activator Inhibitor 1;
Plasminogen Activators*;
Plasminogen*;
Polymorphism, Genetic;
Risk Factors
- From:Korean Circulation Journal
1998;28(7):1105-1111
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: 4G allele of one base pair insertion/deletion polymorphism (4G/5G) at plasminogen activator inhibitor-1 (PAI-1) was associated with increased plasma activity of PAI-1. Increased plasma PAI-1 activity was associated with increase risk of coronary artery disease (CAD). However, there was a controversy whether 4G allele increases the risk of CAD. We investigated relationship between 4G/5G genetic polymorphism and CAD in Korean population. METHODS: We studied 453 patients-145 patients with normal coronary angiogram (NL), 106 with stable angina (SA), 104 with unstable angina (UA) and 98 with myocardial infarction (MI)-characterized by coronary angiography. RESULTS: 1) Korean had higher 4G allele frequency than Caucasian (4G:5G=0.60:0.40 in Korean). 2) There were no allele or gene frequency difference of 4G/5G polymorphism between CAD group and NL group (4G:5G=0.61:0.39 in CAD, 0.59:0.41 in NL, p=0.58). 3) 4G allele was not associated with increased risk of acute coronary syndrome (4G:5G=0.60:0.40 in SA, 0.59:0.41 in UA, and 0.57:0.43 in MI, p=0.84). 4) 4G allele had no influence on progression of coronary artherosclerosis (4G:5G=0.58:0.42 in single vessel disease, 0.58:0.42 in two vessel disease, and 0.56:0.44 in three vessel disease, p=0.82). 5) 4G was not an independent risk factor of CAD even after adjusted with other risk factors. CONCLUSION: In Korean, 4G/5G polymorphism of PAI-1 gene has no relationship with development, progression of coronary artery disease.
