Genetic association of 5-HTR2A 102 T/C polymorphism with Tourette syndrome in a family-based association study in a Chinese Han population

VernacularTitle:中国汉族Tourette综合征患者HTR-2A 102T/C多态性的家系关联分析
Author: Lanlan ZHEN ; Ruiling ZHOU ; Tao YUE ; Xinhua ZHANG ; Xueqin WANG ; Weihua JIANG ; Shiguo LIU
Publication Type:Journal Article
Keywords: Tourette syndrome; HTR-2A 102 T/C; Transmission disequilibrium test; Haplotype relative risk
From: Chinese Journal of Behavioral Medicine and Brain Science 2012;(11):1003-1005
CountryChina
Language:Chinese
Abstract: Objective To investigate whether polymorphism of 102 T/C in 5-HTR2A (serotonin receptor 2A) are associated with Tourette syndrome (TS) in Chinese Han population or none.Methods A total of 101 TS patients and their parents were recruited for the study.The genetic contributions of the 5-HTR-2A 102 T/C polymorphism in 5HTR2A were evaluated using polymerase chain reaction and restriction enzyme digestion (PCRRFLP) and haplotype relative risk (HRR) and transmission disequilibrium test (TDT) statistics.Results The results revealed no significant associations between the 5-HTR-2A 102 T/C polymorphism and TS (HTR-2A 102T/C,TDT =0.353,df=1,P =0.621 ;HRR =1.127,x2 =0.358,P =0.550,95％ CI:0.762-1.666).Conclusion The data suggest that the HTR-2A 102 T/C polymorphism may not be associated with susceptibility to TS in the Chinese Han population.However,these results need to be replicated using larger datasets collected from different populations.