Case-control study on the serum sex steroids levels in prepuberal children with autism
10.3760/cma.j.issn.1674-6554.2012.11.010
- VernacularTitle:青春前期孤独症患儿血清性激素水平变化的病例对照研究
- Author:
Cong YOU
;
Hongzhu DENG
;
Chaoqun CEN
;
Chun TANG
;
Jianying LI
;
Xiaobing ZOU
- Publication Type:Journal Article
- Keywords:
Autism;
Sex steroids;
Progesterone
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;(11):991-993
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of the serum sex steroids levels in prepuberal children with autism,and analyze the possible clinical implications.Methods The serum sex steroids,including folliclestimulating hormone(FSH),luteotropic hormone(LH),testosterone(T),estradiol(E2),progesterone(P),dehydroepiandrosterone sulfate(DHEA-S) and androstenedione were measured in 44 autistic children(35 boys and 9girls,47.5 ± 18.9 months) and 44 normal children(35 boys and 9 girls,45.0 ± 18.7 months),using chemiluminescence immunoassay.Results ①The progesterone levels in autism group were significantly lower than control group((＜ 0.48,2.08) nmoL/L vs (＜ 0.48,6.95) nmol/L,Z =-3.564,P ＜ 0.01),but no statistical differences were observed in other sex steroids levels(P＞ 0.05).②The progesterone levels in ＜ 48 months autism group showed no significant differences from ≥48 months autism group (Z =0.150,P ＞ 0.05).There were no statistical differences in progesterone level between the boys and girls of the autism group(Z=1.972,P＞0.05).Conclusion The progesterone levels are lower in autistic children,and they are not associated with the children's age or gender.This study indicates that the progesterone levels are closely associated with autism.
