Relationship between regional homogeneity of depressed patients and anxious symptoms: a resting-state fMRI study
10.3760/cma.j.issn.1674-6554.2012.11.009
- VernacularTitle:抑郁症患者静息态脑活动与焦虑症状的相关性
- Author:
Rui YAN
;
Zhijian YAO
;
Li HAN
;
Hao TANG
;
Guoping LUO
;
Qing LU
- Publication Type:Journal Article
- Keywords:
Depression;
Anxiety/somatization factor;
Resting-state;
Functional MRI;
ReHo
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;(11):988-990
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the differences of regional homogeneity(ReHo) in depressed patients with vary degrees of anxiety using resting-state function MRI,and the relationship vary degrees of anxiety symptoms.Methods 10 depressed patients with scores less than 1 in anxiety/somatization factor of Hamilton depression scale,10 depressed patients with scores above 2,and 10 age-,gender-,education-matched healthy controls were underwent resting-state fMRI scanning at 3.0 Tesla.Correlation analysis between ReHo with significant differences level of brain region and the total score of Hamilton depression scale,and anxiety/somatization factor were underwent respectively.Results The brain regions with significant difference level among three groups were the left posterior cerebellum(-39,-77,-29 ; K =15),the left angular gyrus (-56,-63,22 ; K =13) and the left anterior cingulate (-3,22,29 ; K =19) (P ＜ 0.05,Alphasim) ; compared with healthy group,the mild anxiety group showed significantly decreased ReHo in the left posterior cerebellum,and increased ReHo in the left anterior cingulate; the moderate and severe anxiety group showed significantly decreased ReHo in the left posterior cerebellum,and increased ReHo in the left anterior cingulate and the left angular gyrus; no significant differences were found in patient groups.In the mild anxiety group,the left anterior cingulate positively correlated with the anxiety severity(r=0.646,P=0.043),and in the severe anxiety group positively correlated with the somatic anxiety(r =0.693,P=0.038).Conclusion Depressed patients showed abnormal neural activity in resting state,and the degree of abnormality is associated with clinical anxiety/somatization symptoms.
