A meta-analysis on the timing of parenteral nutrition and enteral nutrition in acute pancreatitis
10.3760/cma.j.issn.1674-635X.2012.06.007
- VernacularTitle:不同时间开始的肠外营养与肠内营养对急性胰腺炎影响的对比
- Author:
Sumei CHEN
;
Guangsu XIONG
;
Shuming WU
- Publication Type:Journal Article
- Keywords:
Acute pancreatitis;
Enteral nutrition;
Total parenteral nutrition;
Nutrition time;
Meta-analysis
- From:
Chinese Journal of Clinical Nutrition
2012;(6):363-368
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect of parenteral nutrition and enteral nutrition with different start time on acute pancreatitic patients.Methods Randomized controlled trials comparing enteral and parenteral nutrition in acute pancreatitic patients published from January 1996 to January 2011 were searched in MEDLINE,EMBASE,Cochrane databases,Wanfang science library,and China National Knowledge Infrastructure.The information about study design,patient characteristics,and outcomes were extracted by two independent analysers before processed with RevMan 4.2 software.Results Altogether 14 trials were included.When started after 24 hours of admission,enteral nutrition,in comparison with total parenteral nutrition,resulted in a statistically significant reduction in the risks of infections (P =0.0004),surgical intervention (P =0.0200),organ failure (P =0.0400),and morality (P =0.0002) in acute pancreatitic patient.When started within 48 hours of admission,enteral nutrition,in comparison with total parenteral nutrition,resulted in a statistically significant reduction in the risks of infections (P =0.0000),surgical intervention (P =0.0001),organ failure (P =0.0006),and mortality (P =0.0300) in acute pancreatitic patients.Conclusions The time of the commencement of nutriton has an influence on the benefits of enteral nutrition.Enteral nutrition started between 24 hours and 48 hours of admission is more effective than within 24 hours or after 48 hours of admission.
