Study of the effect of edaravone on the expression of intercellular adhesion molecule-1 and tumor necrosis factor-α in Rat brain of cerebral ischemia reperfusion
10.3760/cma.j.issn.1008-6706.2012.24.023
- VernacularTitle:依达拉奉对缺血再灌注后大鼠脑组织细胞间黏附分子-1、肿瘤坏死因子-α表达的影响
- Author:
Xinhong XUE
;
Xiaoming ZHAO
;
Shuzhen WANG
;
Jiang ZHANG
;
Yanbo PENG
;
Dali WANG
- Publication Type:Journal Article
- Keywords:
Hypoxia-ischemia,brain;
Reperfusion injury;
Intercellular adhesion molecule-1;
Tumor necrosis factor-α;
Rats;
Edaravone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;(24):3723-3725
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect the edaravone on the expressions of ICAM-1,TNF-α after focal cerebral ischemia reperfusion in male rats.Methods 45 male SD rats were selected and randomly assigned into 3 groups:sham operation group(SO),ischemia reperfusion group(I/R),and edaravone treatment group(ED),each group had 15 rats.The expression of ICAM-1,TNF-α were checked by immunohistochemistry.All data in the groups were analyzed with t test.Results The expression of ICAM-1 and TNF-α in the I/R group and ED group were higher than the SO group(t=21.919,27.758,26.576,17.395,32.821,43.021,14.195,31.828,21.201,10.195,25.768,17.900,all P＜0.05)at reperfusion 3 hours,6 hours,and 12 hours.The expression of ICAM-1 and TNF-α in the I/R group were higher than the ED group(t=9.623,13.845,7.201,11.313,all P＜0.05)at reperfusion 3 hours and 6 hours.Conclusion Edaravone may exert the neuroprotective effect against the cerebral ischemia in rats by decreasing the expression of ICAM-1 and inhibiting the activation of TNF-α.This process could inhibit free radical generation.
