The differences of clinical profiles by house dust mite sensitization in patients with asthmatics in Soonchunhyang University Hospital cohort.
- Author:
Jung Hyun KIM
1
;
An Soo JANG
;
Shin Ok JEONG
;
Young Seok JI
;
Hyun Jung SEO
;
Jae Hyung NAM
;
Jong Joo MOON
;
Ae Rin BAEK
;
Jong Sook PARK
;
June Hyuk LEE
;
Sung Woo PARK
;
Do Jin KIM
;
Choon Sik PARK
Author Information
- Publication Type:Original Article
- Keywords: House dust mite; Atopy; Asthma; Cohort
- MeSH: Asthma; Body Mass Index; Cohort Studies; Dermatophagoides farinae; Dermatophagoides pteronyssinus; Dust; Eosinophils; Female; Forced Expiratory Volume; Humans; Immunoglobulin E; Immunoglobulins; Inflammation; Korea; Lung; Male; Prevalence; Pyroglyphidae; Sputum; Vital Capacity
- From:Allergy, Asthma & Respiratory Disease 2013;1(1):50-54
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: The majority of patients with allergic disease are highly sensitized to house dust mites (HDM). There is few data to observe sensitization rate to HDM in asthmatics in Korea. The aim of this study was to observe the differences of clinical profiles by HDM sensitization in patients with asthmatics in Soonchunhyang University Hospital (SCH) cohort. METHODS: We recruited 2,345 asthmatic patients in SCH cohort. Lung function, body mass index and sputum and blood eosinophils, and PC20, and clinical profiles were compared by HDM sensitization. RESULTS: Dermatophagoides farinae (Derf) and/or Dermatophagoides pteronyssinus (Derp) (+) sensitization rate was higher prevalence in male than in female. Compared with nonatopy asthmatics, Derf and/or Derp (+) asthmatics had early onset of age [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 32.5+/-0.51 vs. 36.1+/-0.88 vs. 43.1+/-0.54, P<0.05]. Derf and/or Derp (+) asthmatics had shorter duration of asthma symptom than that of nonatopy asthmatics. Derf and/or Derp (+) asthmatics had lower forced expiratory volume in one second and forced vital capacity than those of Derf and Derp (-) asthmatics. PC20 in Derf and/or Derp (+) asthmatics had lower than those of Derf and Derp (-) and nonatopy asthmatics [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 5.4+/-0.24 mg/mL vs. 6.59+/-0.52 mg/mL vs. 7.19+/-0.33 mg/mL, P<0.05]. Blood eosinophils number in Derf and/or Derp (+) asthmatics had higher than that of nonatopy asthmatics (414.7+/-131.1 vs. 350.6+/-14.0, P<0.05). Total immunoglobulin E (IgE) in Derf and/or Derp positive asthmatics had higher than that of Derf and Derp negative and nonatopy asthmatics. There was no difference of body mass index among three groups. CONCLUSIONS: Our data indicate that atopy asthmatics sensitized to Derf and/or Derp had early onset of age, high total IgE and airway responsiveness, and eosinophilic inflammation.
