Clinical observation and cost-effectiveness of warfarin and aspirin for ischemic stroke prevention in elderly patients with atrial fibrillation
10.3760/cma.j.issn.1673-4904.2012.34.004
- VernacularTitle:华法林与阿司匹林预防老年心房颤动患者缺血性卒中的临床比较及成本-效果分析
- Author:
Yanping WU
- Publication Type:Journal Article
- Keywords:
Warfarin;
Aspirin;
Atrial fibrillation;
Cerebrovascular accident;
Costeffectiveness analysis
- From:
Chinese Journal of Postgraduates of Medicine
2012;(34):11-13
- CountryChina
- Language:Chinese
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Abstract:
Objective To study warfarin and aspirin for ischemic stroke prevention in elderly patients with atrial fibrillation.Methods Fifty-three elderly patients with atrial fibrillation from January 2007 to December 2009 were enrolled in this study.All patients were divided into two groups by random digits table method:warfarin group treated with warfarin and aspirin group treated with aspirin.Incidence rate of ischemic stroke,side effect and cost-effectiveness were compared between two groups.Results Forty-nine patients were followed up,the dropout rate was 7.5％(4/53),28 patients in warfarin group,21 patients in aspirin group.Incidence rate of ischemic stroke in warfarin and aspirin group was 3.6％(1/28) and 28.6％(6/21),and there was significant difference (x2 =4.28,P ＜0.05).No significant difference was observed for side effect between two groups (x2 =0.07,P ＞ 0.05).For cost-effectiveness analysis,the ratio of cost-effectiveness was 16.3 yuan and 10.4 yuan in warfarin and aspirin group respectively,and there was significant difference (P ＜ 0.05).Conclusion Warfarin is more effective for ischemic stroke prevention in elderly patients with atrial fibrillation,but costs more than aspirin.
