Investigation of the changes of plasma interleukin-6, interleukin-8, tumor necrosis factor-alpha in acute blood loss patients
10.3760/cma.j.issn.1673-4904.2012.33.002
- VernacularTitle:急性失血患者血浆白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α和一氧化氮合酶的变化探讨
- Author:
Jun WANG
;
Xiaoguang XIU
;
Yanni SUN
;
Shenglin ZHANG
- Publication Type:Journal Article
- Keywords:
Interleukin-6;
Interleukin-8;
Tumor necrosis factor-alpha;
Nitric oxide synthase;
Blood loss
- From:
Chinese Journal of Postgraduates of Medicine
2012;(33):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and significance of plasma interleukin (IL)-6,IL-8,tumor necrosis factor-alpha (TNF-α) and nitric oxide synthase (NOS) in acute blood loss patients.Methods The levels of plasma IL-6,IL-8,TNF-α and NOS were determined in 25 patients with acute blood loss(blood loss group) and 25 healthy controls(control group) by enzyme linked immunosorbent assay.Result The levels of plasma IL-6,IL-8,TNF-α and NOS in blood loss group were higher than those in control group (0.284 ± 0.027 vs.0.204 ± 0.016,0.059 ± 0.079 vs.0.037 ± 0.039,0.460 ± 0.024 vs.0.372 ±0.018,0.637 ±0.054 vs.0.443 ±0.040,P＜0.05 or ＜0.01).Conclusions First,the expressions of IL-6,IL-8,TNF-α and NOS are strongly induced at the circumstances of acute early stage blood loss which can cause inflammatory reaction,aggravate the damage of soft tissues and organs,and easy to lead the blood loss to uncontrolled hemorrhagic shock.Second,the expression of NOS is strongly induced at the circumstances of acute blood loss which should reduce the damage of soft tissue,and alleviate the hemorrhagic shock.Therefore,the levels of plasma IL-6,IL-8,TNF-α and NOS can estimate the illness prognosis and curative effect,which have important clinical instruction value for effective treatment of hemorrhagic shock.
