Relationship between urinary albumin excretion rate and cardiac structure and function in type 2 diabetes mellitus
10.3760/cma.j.issn.1673-4904.2012.31.003
- VernacularTitle:2型糖尿病尿白蛋白排泄率与心脏结构和功能的相关性
- Author:
Zhi YAO
;
Yuan XU
;
Li WANG
;
Ning YANG
;
Yumei JIA
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Albuminuria;
Cardiac structure;
Cardiac function
- From:
Chinese Journal of Postgraduates of Medicine
2012;(31):7-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between urinary albumin excretion rate(UAER)and cardiac structure and function in type 2 diabetes mellitus(T2DM).Methods Five hundred and twenty patients with T2DM were divided into three groups by 8 h UAER:normoalbuminuria group(424 cases),microalbuminuria group(75 cases)and macroalbuminuria group(21 cases).At the same time,50 healthy people were selected as control group.The cardiac structure and function in four groups were evaluated by echocardiographic measurements.Results Left atrial dimensio[(34.39±3.46)mm],left ventricular posterior wall thickness[(10.34±1.05)mm],relative wall thickness(0.46±0.05),interventricular septal thickness[(10.49±1.07)mm],left ventricular mass[(167.37±32.12)g],left ventricular mass index[(87.62±12.16)g/m2]in macroalbuminuria group were significantly higher than those in control group[(32.59±2.71)mm,(9.30±0.77)mm,0.42±0.04,(9.75±0.81)mm,(147.33±27.23)g,(80.14±13.81)g/m2](P＜0.05),mean while the ratio of E/A(0.82±0.19)in macroalbuminuria group was significantly lower than that in control group(1.21±0.16)(P＜0.05).Conclusions In T2DM patients with albuminuria,the cardiac structure and function have changed.With the increase of UAER,the impairments are more prominent.And it may predict diabetes cardiomyopathy.
