Correlation analysis between interleukin-18,interleukin-1β,copeptin and acute cerebral infarction
10.3760/cma.j.issn.1673-4904.2012.31.002
- VernacularTitle:白细胞介素-18、白细胞介素-1β、和肽素与急性脑梗死的相关性分析
- Author:
Yan ZHAO
;
Xiangling MA
;
Yanmei ZHANG
;
Xiangdong CHEN
;
Bin LIN
;
Jin ZHEN
;
Yinling FENG
- Publication Type:Journal Article
- Keywords:
Interleukin-1 beta;
Interleukin-18;
Copeptin
- From:
Chinese Journal of Postgraduates of Medicine
2012;(31):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic changes of serum interleukin(IL)-18,IL-1β and copeptin in acute cerebral infarction(ACI),and analyze the relationship with the serious degree of ACI.Methods The levels of serum IL-18,IL-1β and copeptin were measured by Double-antibody sanduicb enzyme-linked immunosorbent assay(ELISA)in 83 patients with ACI who were admitted to the hospital within 24 h,and neurological impairment were evaluated by European stroke scale(ESS)at the 1st,3rd and 7th day respectively after hospitalization.At the same time,the patients with ACI were compared with 32 normal adults.Results The levels of serum IL-18,IL-1β and copeptin at the 1st,3rd and 7th day after hospitalization were(131.30±31.62),(168.30±28.12),(141.26±24.23)ng/L,(0.35±0.04),(0.82±0.10),(0.52±0.21)μ g/L,and(3.64±0.26),(4.18±0.53),(3.26±2.41)μ g/L respectively.There were significant differences among different times respectively(P＜0.05),furthermore they were higher than those in normal adults[(119.12±27.42)ng/L,(0.21±0.08)μ g/L,(2.63±0.23)μ g/L](P＜0.05).Univariate Logistic regression analysis showed that age,copeptin,IL-18,IL-1β and ESS score was the influencing factor in the serious degree of ACI.There was no significant difference in assessing the serious degree of ACI by receiver operating characteristic(ROC)curve between IL-18 and age,copeptin,IL-1 β,ESS score(P＞0.05).Conclusions The serum levels of IL-18,IL-1β and copeptin are increasing after ACI,indicating that the inflammatory and immune factors may be involved in the development process of ACI.The serum levels of IL-18,IL-1β and copeptin can reflect the serious degree of ACI.
