The clinical characteristics in infantile bronchiolitis and pneumonia according to respiratory syncytial virus subgroups: experience of single tertiary medical center from 2010 to 2012.
- Author:
Ga Hyun YOON
1
;
Yeo Hyang KIM
Author Information
- Publication Type:Original Article
- Keywords: Infant; Respiratory syncytial viruses; Bronchiolitis; Pneumonia
- MeSH: Auscultation; Bronchiolitis; Hospitalization; Humans; Infant; Pneumonia; Recurrence; Respiratory Sounds; Respiratory Syncytial Viruses; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Seasons; Thorax; Viruses
- From:Allergy, Asthma & Respiratory Disease 2013;1(1):84-89
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: The most common cause of bronchiolitis and pneumonia in infants is respiratory syncytial virus (RSV). We evaluated the clinical characteristics according to RSV subgroup in infantile bronchiolitis and pneumonia. METHODS: This study enrolled infants with bronchiolitis or pneumonia infected by single virus. Virus infection was confirmed by respiratory virus reverse transcriptase polymerase chain reaction in two consecutive seasons (2010-2011, 2011-2012). They were divided into 3 groups: group 1 with RSV A, group 2 with RSV B, and group 3 with other virus. We retrospectively reviewed the medical charts to collect data on the hospitalized patients. RESULTS: Seventy four and 181 infants were included in the two seasons, respectively. The most common virus was RSV B in 2010-2011 and RSV A in 2011.2012. Among 255 infants, 55% (141/255) were group 1, 20% (49/255) group 2, 25% (65/255) group 3. Infants younger than 3 months were 55%. There were no significant age differences between groups. In comparison to group 3, group 1 and 2 showed frequent abnormal chest auscultation, high symptom severity score and need for systemic corticosteroid (P<0.05). In comparison to group 1 and 3, group 2 had longer hospitalization and time to need for normalization of lung sound (P<0.05). The recurrence rates within 6 months showed no significant differences between groups. CONCLUSION: The RSV subgroup changed from one year to another. Patients' clinical manifestations and symptom severity may vary according to infected virus subgroup.
