MMP-9 gene polymorphism and cancer risk: a meta-analysis
10.3760/cma.j.issn.1673-422X.2012.012.020
- VernacularTitle:基质金属蛋白酶9基因多态性与肿瘤易感性Meta分析
- Author:
Tong SU
;
Li SHI
;
Gaijie WEI
;
Jing CHEN
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase 9;
Polymorphism,single nucleotide;
Neoplasms;
Meta-analysis
- From:
Journal of International Oncology
2012;(12):945-949
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between MMP-9 rs3918242 C ＞ T polymorphism and cancer risk.Methods PubMed database was utilized to search the relative artiles concerning association between MMP-9 rs3918242 C ＞T polymorphism and cancer risk (last search updated on April 2011).All the statistical analysis was performed by STATA software.Results 4,124 cancer patients and 4,728 control subjects were included in this meta-analysis.No association was observed in the overall analysis (allelic contrast P=0.378,OR =0.94,95％ CI:0.83-1.07).However,in the stratified analysis by cancer type,MMP-9-1562 T allele was found to decrease the lung cancer(P =0.026,OR =0.70,95％ CI:0.5 1-0.96) and colorectal cancer(P=0.016,OR =0.80,95％ CI:0.66-0.96).Conclusion MMP-9 rs3918242 C/T polymorphism is correlated with colorectal cancer and lung cancer.
