Significance of microsatellite instability in colorectal cancer
10.3760/cma.j.issn.1673-422X.2012.012.017
- VernacularTitle:微卫星不稳定性在结直肠癌中的意义
- Author:
Wenxue ZHI
;
Susheng SHI
- Publication Type:Journal Article
- Keywords:
Microsatellite instability;
Colorectal neoplasms;
Prognosis;
Drug therapy
- From:
Journal of International Oncology
2012;(12):935-938
- CountryChina
- Language:Chinese
-
Abstract:
Microsatellite instability (MSI) is an important molecular mechanism in colorectal cancer's initiation and progression,which has significant clinical significance.MSI is a diagnostic biomarker for Lynch synchrome.Moreover,the clinical implication of MSI testing extends to the role of prognostic marker and predictive maker,due to the better outcome of patients with MSI positive colorectal cancer and a general lack of response to chemotherapy employing 5-fluorouracil.
