Anticancer effect of crocin
10.3760/cma.j.issn.1673-422X.2012.012.010
- VernacularTitle:藏红花素的抗肿瘤作用
- Author:
Dan XIA
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Cell cycle;
Apoptosis
- From:
Journal of International Oncology
2012;(12):910-912
- CountryChina
- Language:Chinese
-
Abstract:
Crocin is a chemical extraction from saffron and it is the most important kind of pigment of saffron.Recently,the research on cervical cancer,bladder cancer,leukemia,tongue squamous cell carcinoma,colon cancer,pancreatic cancer shows that crocin has a role in inducing apoptosis of the tumor cells by activating caspase-3,regulating the ratio of bcl-2/bax and repressing the expression of survivin.Crocin has a strong inhibitory effect on tumor proliferation by inducing cell cycle to arrest through down-regulating the expression of cyclin D1 and up-regulating the expression of p27kip1.Crocin can also exert antitumor effects by liposome encapsulation to enhance cytotoxic effect.Crocin is a kind of effective chemical for tumor treatment and prevention with no significant toxico-and by-effect in vivo,and is likely to be used as an anticancer drug clinically in the future.
