Anti-tumor effect of type Ⅲ interferon

VernacularTitle:Ⅲ型干扰素的抗肿瘤作用
Author: Qing WANG ; Lu ZHANG ; Qianni SHEN ; Ni ZHU ; Fan LUO ; Wei HOU
Publication Type:Journal Article
Keywords: Interferons; Neoplasms
From: Journal of International Oncology 2012;(12):905-907
CountryChina
Language:Chinese
Abstract: It is reported that type Ⅲ interferon (IFN-λ) has an anti-tumor effect on melanoma,hepatocellular carcinoma,esophageal carcinoma and fibrosarcoma in recent years.IFN-λ could not only inhibit melanoma metastasis,but also induce cell apoptosis;its constitutively expression could activate natural killer cells,affecting hepatocellular carcinoma growth;IFN-λ could induce cells of G1 phase in esophageal carcinoma directly to stagnation or apoptosis;IFN-λ could cause native and adaptive immune response to suppress fibrosarcoma growth.Research on the anti-tumor mechanisms of IFN-λ will provide new ideas for clinical tumor therapy.