Formation of hypoxic microenvironment of cancer stem cells and its role in tumor metastasis
10.3760/cma.j.issn.1673-422X.2012.011.004
- VernacularTitle:肿瘤干细胞缺氧微环境的形成及其对肿瘤转移的促进作用
- Author:
Honghai WANG
;
Lianhong LI
- Publication Type:Journal Article
- Keywords:
Neoplastic stem cells;
Anoxia;
Hypoxia-inducible factor 1;
Neoplasm metastasis
- From:
Journal of International Oncology
2012;(11):812-814
- CountryChina
- Language:Chinese
-
Abstract:
Cancer stem cells located in specific microenvironment,that play an important role in the proliferation and metastasis of tumor cells.Hypoxia is one of the important features of tumor tissue microenvironment.A series of studies results show that the hypoxic microenvironment of tumor stem cells could promote tumor metastasis,which provides new clues for understanding tumor pathogenesis and tumors treatment.
