Clinical therapeutis effect of ginsenoside Rg3 plus chemotherapy on serum vascular endothelial growth factor in aged gastric cancer patients
10.3760/cma.j.issn.0254-9026.2012.12.012
- VernacularTitle:人参皂甙Rg3联合化疗对老年胃癌患者血管内皮生长因子的影响及疗效
- Author:
Yuanming JING
;
Feiying YANG
;
Minfeng YE
;
Feng TAO
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Vascular endothelial growth factors;
Angiogenesis inhibitors;
Ginsenoside
- From:
Chinese Journal of Geriatrics
2012;(12):1076-1078
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of ginsenoside Rg3 combined with XELDX regimen on advanced carcinoma of stomach.Methods Totally 93 postoperative patients with advanced gastric cancer were randomly divided into two groups:control group(n ＝ 53) who received only XELDX regimen,and study group (n＝ 40) who were treated with ginsenoside Rg3 + XELDX.The objective response rate,KPS score and serum VEGF levels in the two groups were detected.Results (1) Before treatment,treatment group and control group showed that serum VEGF levels were (387.63±159.74) μg/L and (378.56± 169.36) μg/L,respectively (P＜0.05).After 8 weeks of treatment,serum VEGF of the treatment group decreased to (207.74 ± 115.71) μg/L,the level of the control group VEGF decreased to (246.53 ±107.63) μg/L(P＜0.05).(2) The efficacy rate was 57.5％ (23/40) in treatment group and 45.3％(24/53) in the control group (P＞0.05).(3) KPS score increasing rate was higher in treatment group (65.0％) than in control group (39.6％)(x2＝5.87,P＜0.05).Conclusions Ginsenoside Rg3 combined with chemotherapy in advanced gastric cancer patients can reduce serum VEGF levels and improve the quality of life of patients.
