Effectiveness of combined alprostadil and pancreatic kininogenas in treating gerontal diabetic peripheral neuropathy

VernacularTitle:前列地尔联合胰激肽原酶治疗老年人糖尿病周围神经病变的疗效观察
Author: Yu ZHANG ; Hongshuang DAI ; Jiaqing FENG
Publication Type:Journal Article
Keywords: Alprostadil; Kallidin; Diabetic neuropathies
From: Chinese Journal of Geriatrics 2012;(12):1070-1072
CountryChina
Language:Chinese
Abstract: Objective To observe the clinical effectiveness of alprostadil combined to pancreatic kininogenas in the treatment of gerontal diabetic peripheral neuropathy.Methods Totally 90 gerontal patients with diabetic peripheral neuropathy were randomly divided into three groups,the first group received the treatment of mecobalamin,the second group received mecobalamin plus pancreatic kininogenas,the last group received mecobalamin,alprostadil and pancreatic kininogenas (30 cases for each).The course of treatment was 4 weeks,the nerve conduction and effective rate of 3 groups were compared after treatment.Results Compared with the first group(53.3％),the total effective rate was significantly improved in the second group (80.0％)and the third group(100.0％) (P＜0.05).After treatment,the therapeutic effect of every group was boosted,and the second group was better than the first group,and the last group was best(P＜0.05).Conclusions Alprostadil combined to pancreatic kininogenas is effective and safe for the treatment of elderly diabetic peripheral neuropathy.