Relationship of blood pressure variability and angiotensinogen T235M polymorphism with Binswanger's disease
10.3760/cma.j.issn.0254-9026.2012.12.006
- VernacularTitle:血压波动及血管紧张素原M235T基因多态性与皮层下动脉硬化性脑病相关性研究
- Author:
Huifang WEI
;
Lin MA
;
Peiyan SHAN
;
Wenjing JIANG
- Publication Type:Journal Article
- Keywords:
Dementia,vascular;
Angiotensinogen;
Polymophism,single neucleotide;
Blood pressure variability;
Blood pressure
- From:
Chinese Journal of Geriatrics
2012;(12):1056-1059
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the relationship of blood pressure variability (BPV) and angiotensinogen(AGT) T235M polymorphism with Binswanger's disease (BD).Methods Totally 122 cases with BD and 108 cases with essential hypertension had been enrolled.Ambulatory blood pressure monitoring was used to get the data of BPV and mean blood pressure (MBP).PCR-RFLP was applied to detect genotype of AGT T235M.Results Distribution of MM+MT genotype and frequency of M allelic were higher in BD group (51.6％,29.9％) than in hypertension group(27.8％,16.2％)(x2 ＝13.543,11.995,P＜0.01).The variability of night time blood pressure (11.8±2.8,9.1±2.5) and 24 hours diastolic blood pressure(11.6±6.0) in BD group were increased compared with those in hypertension groups(10.9±2.4,8.2±3.2,10.1±4.6)(t＝2.59,2.64,2.09,all P＜0.05).Prevalence of anti-dipper was higher in BD group (32.8％) than in EH group (16.7％)(x2 ＝7.894,P＜0.01).Among BD patients,anti-dipper who carried MM or MT genotypes (44.4 ％) was more than that who carried TT genotype (20.3％) (x2 ＝ 8.760,P＜ 0.01).Conclusions Fluctuations of nighttime blood pressure and diastolic pressure are higher in patients with BD,and the relative frequency of MM or MT genotype is higher.Moreover,among patients with BD who carried MM or MT genotypes are apt to have anti-dipper.MM or MT genotype is related to BD by means of affecting blood pressure circadian rhythms probably.
