Pharmacogenetic research progress of inosine triphosphate pyrophosphatase
10.3760/cma.j.issn.1673-4408.2013.01.007
- VernacularTitle:三磷酸肌苷焦磷酸酶药理遗传学的研究进展
- Author:
Xingjun LI
- Publication Type:Journal Article
- Keywords:
Inosine triphosphate pyrophosphatase;
Purine drugs;
Drug metabolism;
Gene mutation;
Gene polymorphism
- From:
International Journal of Pediatrics
2013;(1):25-27
- CountryChina
- Language:Chinese
-
Abstract:
Purine drugs are for the treatment of autoimmune diseases,organ transplantation,acute lymphoblastic leukemia.The adverse reaction rate is 15％ ～ 28％,which impacts on the clinical application in recent years.Studies have shown that inosine triphosphate pyrophosphatase (ITPA) are different between individuals,and there are adverse reactions in patients with defects of ITPA when purine drugs are used.This paper reviewes the ITPA pharmacogenetic research progresses.
