Progress of miRNA in childhood acute lymphoblastic leukemia
10.3760/cma.j.issn.1673-4408.2012.06.016
- VernacularTitle:miRNA在儿童急性淋巴细胞白血病中的研究进展
- Author:
Feifei SONG
- Publication Type:Journal Article
- Keywords:
miRNA;
Children;
Acute lymphoblastic leukemia;
Diagnosis;
Treatment
- From:
International Journal of Pediatrics
2012;(6):595-597
- CountryChina
- Language:Chinese
-
Abstract:
The non-coding miRNA is classified into different families according to their gene structure and function.It is involved in many cellular processes,such as proliferation,differentiation and apoptosis.Recently it has been proved that miRNA has played an important role in the pathogenesis of many cancers,acting as oncogenic miRNAs or tumor suppressor,including acute lymphoblastic leukemia (ALL).Because miRNA is highly connected with the pathogenesis,diagnosis,prognosis and drug-resistant of childhood ALL,it might be a new breakout for the diagnosis and treatment of ALL.This paper reviews current literatures on miRNA and childhood ALL.
