The therapeutic effect comparative study of botulinum toxin A and baclofen in hemifacial spasm
10.3760/cma.j.issn.1673-4904.2012.34.010
- VernacularTitle:A型肉毒毒素与巴氯芬治疗偏侧面肌痉挛的疗效对比
- Author:
Jinmin XIN
- Publication Type:Journal Article
- Keywords:
Hemifacial spasm;
Botulinum toxins;
Baclofen
- From:
Chinese Journal of Postgraduates of Medicine
2012;(34):29-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the therapeutic effect of local injection of botulinum toxin A (BTXA) and oral baclofen in hemifacial spasm (HFS).Methods Sixty-six patients with HFS were divided into BTXA treatment group (33 patients) and baclofen treatment group (33 patients) by random digits table.The patients in BTXA treatment group was given local multipoint target muscle injection of BTXA,and the patients in baclofen treatment group was given oral baclofen.The therapeutic effect was assessed after treatment of 2 weeks and 4 weeks.Results The scores of spasticity before treatment had no significant difference between two groups (P ＞ 0.05).After treatment of 2 weeks and 4 weeks,the scores of spasticity in BTXA treatment group and baclofen treatment group were significantly decreased [BTXA treatment group:(1.80 ±0.70),(1.57 ± 0.17) scores vs.(3.15 ±0.43) scores;baclofen treatment group:(2.14 ±0.60),(1.14 ± 0.70) scores vs.(3.00 ± 0.48) scores] (P ＜ 0.01).The scores of spasticity in BTXA treatment group after treatment of 2 weeks and 4 weeks were significantly lower than those in baclofen treatment group (P ＜0.05 or ＜0.01).After treatment of 4 weeks,the grades of spasticity between two groups had significant difference (P ＜0.05).The rate of adverse reaction in BTXA treatment group [15.15％ (5/33)] was significantly lower than that in baclofen treatment group [51.52％ (17/33)] (P ＜ 0.01).Conclusions Local injection of BTXA and low dose oral baclofen in treatment of HFS can reach the obvious relief.But BTXA treatment has rapid onset,Iess adverse reaction and high compliance of the patients,and also symptoms improve more completely after BTXA treatment.BTXA can be used as preferred method of treating HFS.
