Clinical observation on the effet of edaravone combined with low-molecular-weight heparin on progressive cerebral infarction

VernacularTitle:依达拉奉联合低分子肝素治疗进展性脑梗死疗效观察
Author: Yulan WANG ; Guoyan ZHU
Publication Type:Journal Article
Keywords: Brain infarction; Low-molecular-weight heparin; Edaravone
From: Chinese Journal of Primary Medicine and Pharmacy 2012;(23):3545-3546
CountryChina
Language:Chinese
Abstract: Objective To study the clinical effect of low-molecular-weight heparin combined with edaravone in the treatment of progressive cerebral infarction.Methods 60 patients with acute progressive cerebral infarction in 72 hours were randomly divided into treatment group received edaravone combined low-molecular-weight heparin(n=30)and control group received low-molecular-weight heparin(n=30).The primary efficacy was evaluated by NIHSS(the National Institutes of Health Stroke Scale).ADL(Activities of daily living)and clinical effect.Results Our study showed that the score of NIHSS on 7th day post-therapy and 14th day post-therapy in treatment group was lower than that in control group(t=15.987 and 11.756,both P＜0.01).However,the score of ADL in the theatment group on 14th day post-therapy was higher than that of control group(t=62.56,P＜0.01).The overall clinical responserate of treatment group was higher than that of control group(x2=13.695,5.769,all P＜0.01).Conclusion Edaravone combined with low-molecular-weight heparin has remakable effect on the treatment of progressive cerebral infarcti.