The influence of edaravone on serum ET,slCAM-1,MCP-1 and neurological function in acute cerebral infarction
10.3760/cma.j.issn.1008-6706.2012.23.022
- VernacularTitle:依达拉奉对脑梗死患者内皮素、可溶性细胞间黏附分子、单核细胞趋化因子及神经功能的影响
- Author:
Haitao LI
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Endothelin;
Soluble intercellular adhesion molecule 1;
Monocyte chemotactic factor 1;
Edaravone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;(23):3562-3563
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of edaravone on serum endothelin(ET),soluble intercellular adhesion moleculel(sICAM-I)and monocyte chemotactic factor 1(MCP-1)and neurological function in acute cerebral infarction patients.Methods 90 patients with acute cerebral infarction were randomly divided into treatment group(additional edaravone)and control group(routine treatment).The serum levels of ET,sICAM-1 and MCP-1were detected by ELESA pretherapy and after treatment.Neurological functional deficit scores(NDS)was utilized for assessment pretherapy and after treatment.Results The levels of serum ET,sICAM-1 and MCP-1 in acute cerebral infarction groups were significantly higher than those of control group(t=4.55,4.62,4.75,4.43,4.61,4.73,all P＜0.05);The levels of serum ET,sICAM-1 and MCP-1,NDS in both two groups after treatment were significantly lower than those before treatment(t=4.12,4.23,4.15,3.91,3.92,3.83,4.52,4.36,all P＜0.05),and the levels of serum ET,sICAM-1,MCP-1 and NDS in the treatment group were significantly lower than those in the control group(t=3.72,3.63,3.53,3.72,all P＜0.05).Conclusion Edaravone can decrease the levels of ET,sICAM-1 and MCP-1in acute cerebral infarction patients.It can lighten acute inflammation and brain injury,protect the tissue of brain.
